According to the latest available information, the following criteria are to be met when sending a specimen either through the U.S. Mail or via private courier services (Federal Express, Airborne, etc.). Read requirements on the Centers for Disease Control
website. Two containers are required:
The labeled specimen must be packed in a securely sealed, crushproof, and liquid-tight (leak-proof) primary container. In most cases, the primary container will be either an evacuated glass tube, vial, jar or bottle with a screw-top cap.
Shipping Glass Test Tubes
We recommend the following procedures when shipping glass tubes. DO NOT FREEZE SPECIMENS IN GLASS TEST TUBES. If glass test tubes must be frozen, they must be placed at a shallow angle slant during freezing to avoid cracking the tube. It is also recommended that the tubes be placed in a capped plastic vial in case of freeze-related breakage.
Glass tubes are to be packed in one of two ways. They may either be individually placed in secondary containment tubes (see below), or they are to be placed in a protective foam box. If a foam box is used, the box is to be placed in a secondary leak-proof container such as a plastic “Ziploc®” bag described below. Do not allow tubes to come in contact with each other to avoid breakage during shipping.
Opened Evacuated Tubes
Once a stopper has been removed, it cannot be replaced in a manner which will prevent leakage during shipment. If the tube has been previously opened, the contents are to be transferred to a screw-top or snap-top plastic tube, with a notation made on the Analysis Requisition as to the nature of the original evacuated tube, e.g. stopper color, and/or preservative.
Each primary container is to be placed in a secondary container. In the case of glass or plastic tubes, the best secondary container is a plastic container (tube) with a larger diameter and a screw-top lid. For all other specimens, a “Ziploc®” bag is appropriate. The purpose of the secondary container is to preserve and protect the specimen(s) if the primary container cracks, to protect other specimens from possible contamination and to protect persons (postal service workers, laboratory staff, etc.) from exposure to potential hazardous substances/materials or biological fluids during their handling.
The secondary container must contain enough absorbent material to absorb the entire liquid contents of the primary container if it should break in transit. All shipping containers must be packaged to fully contain leakage/spillage in accordance with applicable federal laws.
Analysis Requisitions and other documents (i.e. histories, Chain of Custody forms, etc.) are to be placed in a separate pouch or separate sealed plastic bag and must be shipped in the same box containing the specimens.
Shock-absorbent material must be used if multiple specimens are being shipped. It should be adequate to prevent breakage during ordinary handling.
Specimens required to be submitted frozen are to be immediately frozen following collection and shipped in a Styrofoam® container completely filled with a sufficient volume of dry ice in order to preserve the specimens during the anticipated shipping time. Overnight delivery is recommended for all specimen types. Specimens which require refrigerated temperatures should be shipped with cold packs.
Many drugs and other toxins can degrade in the presence of light, even when in a biological sample. This can happen with both natural and artificial light. NMS Labs makes efforts to assess drugs for their light stability as part of our extensive method validation procedure. We require those analytes, which are light sensitive to be collected or stored in a light, protected container, and either amber glass or in a clear glass wrapped with aluminum foil. This, and observing proper storage and shipping temperature helps ensure that the drug concentration present at the time of analysis reflects the concentration at the time the sample was collected, and assists with interpretation and patient care.
Outer Carrier Box
Each set of primary and secondary containers are to be placed in a crush-proof shipping container made of fiberboard or Styrofoam.
External Shipping Labeling
The outer container must be labeled and sealed to indicate that it contains potentially hazardous materials. Biohazard labels must be affixed to the outer container. If dry ice is used this must be noted as dangerous goods on the outer box. Compliance with U.S. Postal and/or commercial carrier requirements is necessary.
Shipping Requirements for Study Specimens
In general, study specimens should be shipped in accordance with the analytical requirements (e.g., frozen, light-protected) and following the guidelines for other specimens listed above. The specimens comprising a batch should be boxed together with the specimen analysis requisitions and other pertinent paperwork. These documents should be contained in a liquid-tight plastic bag or envelope. The shipment should be sent to NMS Labs to the attention of special studies.. If a chain of custody protocol needs to be followed contact NMS Labs for details.
International Shipment of Specimens
The following requirements for AIR MAIL are to be met when sending specimens via private courier services (Federal Express, United Parcel Services, Airborne, etc.). The basic triple packaging system is used with the same requirements as for other means of conveyance. The system consists of three layers as follows:
- Primary Receptacle: A labeled primary watertight, leak-proof receptacle containing the specimen. The specimen must be wrapped with enough absorbent material in order to absorb all fluid in case of breakage.
- Secondary Receptacle: A second durable, watertight, leak-proof receptacle is used to enclose and protect the primary receptacle(s). Sufficient shock absorbent material must be used to cushion multiple primary receptacles.
- Outer Shipping Package: The secondary receptacle is placed in an outer shipping package that protects it and its contents from outside influences such as physical damage and water while in transit.
Specimen data forms, letters and other types of information that identify or describe the specimen must accompany the shipped substances. The address label must display the word “LETTER” and the green Customs Declaration Label for Postal Mail is required for international mailing. Diagnostic specimens are to be identified with the violet UPU “PERISHABLE BIOLOGICAL SUBSTANCES” label. Shipment of diagnostic specimens must meet the UN packaging instructions (PI) 650. Infectious substances are to be identified with the International Infectious Substance label and accompanied with a shipper’s Declaration of Dangerous Goods form. Shipment of infectious substances must meet the UN class 6.2 specifications and packaging instructions (PI) 602.
When dry ice is used in a shipment, it must be placed outside of the secondary receptacle. The secondary receptacle must be secured within the outer package to prevent damage after the refrigerant has melted or dissipated. Dry ice must NOT be placed inside the primary or secondary receptacle to avoid the risk of explosions. An over-pack (a specially designed insulated outer package) may be used to contain dry ice. The outer package must permit the release of carbon dioxide gas if dry ice is used. UN Packing Instruction 904 must be observed. If dry ice is used for infections substances, the details must appear on the Declaration for Dangerous Goods. In particular, the outer most packing must carry the “MISCELLANEOUS” hazard label for dry ice.
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