Benzocaine, Plasma Test (0560P)

Benzocaine, Plasma Test (0560P)

Analysis Code 0560P 
Test Name Benzocaine, Plasma 
Test Includes Benzocaine 
Compound Synonym(s) Americaine®; Baby Anbesol®; Orabase; Oragel 
Purpose Therapeutic Drug Monitoring; This test is New York State approved. 
Category Anesthetic (Topical) 
Method(s) Gas Chromatography/Mass Spectrometry
(GC/MS) 
Specimen Requirements 8 mL Plasma 
Transport Temperature Refrigerated 
Specimen Container NMS Labs has no experimental or literature-based data regarding the choice of specific specimen collection containers for this test. 
Special Handling Step 1: Prepare esterase inhibitor solution (Neostigmine 2 mg/mL): Weigh 68 mg of Neostigmine Bromide (Sigma Chemical, St. Louis, MO) and transfer to a 25 mL volumetric flask. Dissolve and dilute to volume with deionized water, mix thoroughly. Store in an amber bottle at room temperature and discard nine (9) months after preparation. STEP 2: Prepare collection tubes to 3 mL plasma draw tubes containing Na2EDTA anti-coagulant, add 20 microliters of the 2 mg/mL Neostigmine solution without breaking the vacuum. This is accomplished by using a 25 microliter syringe and piercing the rubber top of the container. STEP 3: Collecting samples and storage: Draw blood into the prepared collection tubes, making efforts to draw at least 2.5 mL. Invert tube at least eight (8) times to mix with the EDTA and Neostigmine. Immediately centrifuge and carefully transfer, with plastic pipette, the supernatant plasma into a labeled plastic container. Keep refrigerated and freeze if stored for more than one week. 
Light Protection Required Not Required 
Stability Room Temperature: Undetermined
Refrigerated: Undetermined
Frozen (-20 °C): Undetermined 
*Rejection Criteria None 
Day(s) Test Set-up / TAT [GC/MS] Monday-Friday / 7 days 
Suggested CPT Code 80375 
**Minimum Volume 3.6 mL 
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You are viewing Benzocaine, Plasma Test (0560P)
*Rejection criteria pertain to clinical specimen submissions only.
**Stated minimum volume allows for a single analysis. Repeat analysis will not be performed.


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