Disulfiram (DEDTC Metabolite), Serum/Plasma Test (1790SP)

Disulfiram (DEDTC Metabolite), Serum/Plasma Test (1790SP)

Analysis Code 1790SP 
Test Name Disulfiram (DEDTC Metabolite), Serum/Plasma 
Test Includes Diethyldithiocarbamate 
Compound Synonym(s) Antabuse; DEDTC; Diethyldithiocarbamate; Disulfiram Metabolite 
Purpose Therapeutic Drug Monitoring; Compliance Monitoring; This test is New York State approved. 
Category Alcohol Deterrent 
Method(s) Gas Chromatography (GC) 
Specimen Requirements 7 mL Serum or Plasma 
Transport Temperature Frozen 
Specimen Container Lavender top tube (EDTA) 
Special Handling Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines. 
Light Protection Required Not Required 
Stability Room Temperature: Undetermined
Refrigerated: Undetermined
Frozen (-20 °C): Undetermined

Disulfiram is rapidly and completely reduced to diethyldithiocarbamate (DEDTC) in blood within 4 minutes of addition to human blood or plasma. DEDTC, an excellent chelator of numerous metal ions, has an in vitro half-life of approximately 70 minutes in either human blood or plasma at room temperature, but nonenzymatically degraded (especially in an acid medium) to carbon disulfide and diethylamine.

It is required that specimens be frozen within one hour of drawing blood or urine. In the event that specimens are not frozen within this timeframe the utility of the test is compromised. 
*Rejection Criteria Glass container. Polymer gel separation tube (SST or PST). 
Day(s) Test Set-up / TAT [GC] Sunday / 4 days 
Suggested CPT Code 80375 
**Minimum Volume 3.2 mL 
Test Summary Sheet Generate  

You are viewing Disulfiram (DEDTC Metabolite), Serum/Plasma Test (1790SP)
*Rejection criteria pertain to clinical specimen submissions only.
**Stated minimum volume allows for a single analysis. Repeat analysis will not be performed.


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