Disulfiram (DEDTC Metabolite), Serum/Plasma Test (1790SP)
||Disulfiram (DEDTC Metabolite), Serum/Plasma
||Antabuse; DEDTC; Diethyldithiocarbamate; Disulfiram Metabolite
||Therapeutic Drug Monitoring; Compliance Monitoring; This test is New York State approved.
||Gas Chromatography (GC)
||7 mL Serum or Plasma
||Lavender top tube (EDTA)
||Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines.
|Light Protection Required
||Room Temperature: Undetermined
Frozen (-20 °C): Undetermined
Disulfiram is rapidly and completely reduced to diethyldithiocarbamate (DEDTC) in blood within 4 minutes of addition to human blood or plasma. DEDTC, an excellent chelator of numerous metal ions, has an in vitro half-life of approximately 70 minutes in either human blood or plasma at room temperature, but nonenzymatically degraded (especially in an acid medium) to carbon disulfide and diethylamine.
It is required that specimens be frozen within one hour of drawing blood or urine. In the event that specimens are not frozen within this timeframe the utility of the test is compromised.
||Glass container. Polymer gel separation tube (SST or PST).
|Day(s) Test Set-up / TAT
||[GC] Sunday / 4 days
|Suggested CPT Code
|Test Summary Sheet
*Rejection criteria pertain to clinical specimen submissions only.
**Stated minimum volume allows for a single analysis. Repeat analysis will not be performed.