Purpose
Therapeutic Drug Monitoring; The test is an analytical service for the quantification of busulfan in a specimen. It does not provide an area-under-the-curve (AUC) calculation, busulfan clearance information or a recommendation on adjustment to dosing
Method(s)
High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)
Suggested CPT Code(s)
80375
New York State Approval Status

Approved

Turnaround Time

8 days

Test Includes
1 Busulfan Busulfex®; Myleran® High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS) ng/mL 10 Antineoplastic

Specimen Type
Serum or Plasma
Requested Volume
2 mL
Minimum Volume
0.7 mL
Special Handling
Collect 4 mL of blood in Green top tube (Sodium Heparin).
Blood samples should be placed on wet ice immediately after collection. Centrifuge at 4 degrees Celcius within 1 hour and separate Serum or Plasma into a plastic screw capped vial using approved guidelines. The plasma, harvested into appropriate storage tube should be frozen immediately at -20 degrees Celcius and shipped frozen on dry ice.
Specimen Container
Plastic container (preservative-free)

Additional Collection Instructions

Transport Temperature
Refrigerated
Light Protection
Not Required
Rejection Criteria
Received Room Temperature. Polymer gel separation tube (SST or PST).

Rejection criteria pertain to clinical specimen submissions only.

Stability
Room Temperature: Not Stable
Refrigerated: 7 day(s)
Frozen (-20 °C): 30 day(s)
1 Busulfan Busulfex®; Myleran® High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS) ng/mL 10 Antineoplastic

Interface Map

LOINC® Information