Purpose
Therapeutic Drug Monitoring; Compliance Monitoring
Method(s)
Gas Chromatography (GC)
Suggested CPT Code(s)
80375
New York State Approval Status

Approved

Turnaround Time

8 days

Test Includes
1 Diethyldithiocarbamate Disulfiram Metabolite Gas Chromatography (GC) mcg/mL 0.05 Alcohol Deterrent

Test Also Known As
Antabuse; DEDTC; Diethyldithiocarbamate
Specimen Type
Serum or Plasma
Requested Volume
7 mL
Minimum Volume
3.2 mL
Special Handling
Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines.
Specimen Container
Lavender top tube (EDTA)

Additional Collection Instructions

Transport Temperature
Frozen
Light Protection
Not Required
Rejection Criteria
Glass container. Polymer gel separation tube (SST or PST).

Rejection criteria pertain to clinical specimen submissions only.

Stability
Room Temperature: Undetermined
Refrigerated: Undetermined
Frozen (-20 °C): Undetermined

Disulfiram is rapidly and completely reduced to diethyldithiocarbamate (DEDTC) in blood within 4 minutes of addition to human blood or plasma. DEDTC, an excellent chelator of numerous metal ions, has an in vitro half-life of approximately 70 minutes in either human blood or plasma at room temperature, but nonenzymatically degraded (especially in an acid medium) to carbon disulfide and diethylamine.

It is required that specimens be frozen within one hour of drawing blood or urine. In the event that specimens are not frozen within this timeframe the utility of the test is compromised.
1 Diethyldithiocarbamate Disulfiram Metabolite Gas Chromatography (GC) mcg/mL 0.05 Alcohol Deterrent

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